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Active liver disease or gallbladder problems : GLP-1 use has been linked to gallstone formation in some patients
The pivotal trials for both diabetes and weight management (SUSTAIN and STEP programs) excluded pregnant women and required contraception during participation, limiting our understanding of fertility effects
Genes Dev 20 : 34753486
The American Diabetes Association (ADA) Standards of Care and American College of Physicians (ACP) guidelines support the use of GLP-1 receptor agonists, including dual agonists like tirzepatide, as effective options for glycemic control and weight management
They are often recommended for individuals who struggle to absorb B12 from food or supplements, such as those with certain medical conditions or dietary restrictions
J Toxicol Clin Toxicol 2000, 38: 219-220
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