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doi: 10.1016/j.cell.2016.09.034 156 KleinnijenhuisJQuintinJPreijersFJoostenLAIfrimDCSaeedSet al

This creates a vicious, self-perpetuating cycle: mitochondrial dysfunction causes oxidative stress, and that oxidative stress causes further mitochondrial destruction

found that 4-HNE, a toxic product of lipid peroxidation, serves as a potential mediator linking ferroptosis and inflammation in FRDA fibroblasts (390)