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The rationale for combining them is mechanistic

It does help with insulin resistance

Whether the imidazole rings in these amyloidogenic proteins can capture and sequester deuterium is an open question, but further experimental research will be necessary to resolve it

Nat Med 18:18471856 Schwenk RW, Baumeier C, Finan B et al (2015) GLP-1-oestrogen attenuates hyperphagia and protects from beta cell failure in diabetes-prone New Zealand obese (NZO) mice

Iwasaki Y, Dezaki K, Kumari P, Kakei M, Yada T

In 2019 a multinational collaborative study of data collected in 204 countries and territories between 2000 and 2019 indicated that obesity contributed approximately 5 million deaths from major non-communicable diseases