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There are no direct drug interactions that require discontinuation, though your healthcare provider may recommend temporarily pausing semaglutide if you develop severe vomiting or dehydration

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doi: 10.3390/ijms16010378 8 MurruEMancaCCartaGBanniS

While side effects are similar (mainly gastrointestinal, such as nausea or diarrhea), some patients may find Tirzepatides dual mechanism offers improved tolerability