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The case for considering it is straightforward: the underlying drug class (GLP-1 receptor agonists) has the strongest weight management evidence base in clinical pharmacology, supported by multiple large-scale randomized controlled trials showing 15-22% weight reduction in study populations over 68-72 weeks
doi: 10.1186/s13075-017-1357-2 187 LiMLiuXSunXWangZGuoWHuFet al
Something metabolic was working against me, and I couldnt out-effort it
If your genetics show reduced GLP-1 receptor sensitivity, pharmaceutical semaglutide becomes especially valuable because it overcomes your natural limitations
Phase 2 trial in type 2 diabetes (Lancet 2023) also showed superior weight loss for the combination versus either monotherapy
Weight loss begins in earnest
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