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Animal research suggests several converging mechanisms: modulation of the nitric oxide pathway , upregulation of VEGF driving angiogenesis, interaction with the growth-hormone-receptor pathway , and modulation of inflammatory cytokines including TNF- and IL-6
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Bone 87 , 130135 (2016)
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Depending on the different types of GLP-1-based medications, HbA1C reduction has been shown to range between -0.7 and -2.5%
Zepbound (tirzepatide) studies generally show marginally better average weight loss outcomes compared to semaglutide at equivalent doses but Wegovy is highly effective, extensively studied, and costs the same copay on plans where it's preferred
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