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In contrast, NAC 900 mg TID reduced FEV 1 decline (by 150 mL) versus placebo over 24 weeks, though primary endpoints were unmet due to underpowering (108)

doi: 10.1111/jcmm.18173 100 RosasSKwokAMooreJShiLSmithTLTallantEAet al

Dose selection should be based on treatment response, tolerability, clinical goals, and the specific medications prescribing instructions

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Studies assess impacts on luteinizing hormone, follicle-stimulating hormone, and sex steroid balance in adults

Dose stability: Side effects are most intense during dose escalation