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While some people continue using GLP-1 for an extended period to maintain their weight loss, its not necessary to take it for life
GLP-1 Receptor Agonists: Have transformed the treatment options for type 2 diabetes and obesity
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Semaglutide remains valuable for patients who tolerate it well, patients with specific cost considerations, or patients who need a longer established safety record
Int J Obes Relat Metab Disord
Animal data on LR3 infusion in pigs showed continued suppression of plasma growth hormone (~23% decrease) and IGFBP-3 across the 4-day infusion window (Tomas et al., 1997) by days 8-10 of a 10-day human community protocol, this kind of HPG-axis suppression would be expected to be active
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