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The trial design thus built on the pharmacokinetic strengths of the compound, allowing for flexibility in real-world scenarios of non-adherence
They no longer want to lose more weight and are focusing on stability
This creates a compounding effect where both the medications direct effects AND the weight loss contribute to reduced tolerance
doi: 10.1016/j.fct.2014.07.027 37 MiyachiM.MatsunoT.AsanoK.MatagaI
The most common side effects are mild to moderate gastrointestinal effects, such as nausea, constipation, and vomiting
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