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The major proglucagon fragment: an abundant islet protein and secretory product

The analogue, liraglutide, was effective in clinical studies (the LEAD trials [16]) and was subsequently tested in a cardiovascular outcome trial, the LEADER trial [17], as demanded by the FDA for new antidiabetic agents

The underlying mechanism of these beneficial effects has been further investigated by Ohyama et al

Amylin and GLP-1 are two different hormones that both reduce appetite but through different brain pathways

In a B16 melanoma cell model, hydroxytyrosol reduced melanin production by 65%, resulting in brighter, more translucent skin

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