Similar Elimination Rates of Glucagon-Like Peptide-1 in Obese Type 2 Diabetic Patients and Healthy Subjects
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In preclinical studies conducted on cynomolgus monkeys it has shown agonistic activity to human and cynomolgus GLP-1 receptors and improved glucose tolerance by stimulating insulin secretion, and it exhibited an anti-feeding activity like exenatide
-Average weight loss of 21.4% at the 10 mg dose, and 16% at the 5mg dose at 72 weeks
Researchers assessed the livers capacity for urea nitrogen synthesis (CUNS) as an index of nitrogen processing, examined mRNA expression levels of urea cycleassociated enzymes, determined whole-body nitrogen equilibrium, and estimated nitrogen distribution among major organs