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The GLP-1R is a G-protein coupled receptor that has wide tissue expression, including in the brain, the wall of the portal vein near the hilus of the liver, and arteries and arterioles from various organs (kidney, heart, pancreas, and intestine) [18]
Generally, rectal suppositories start to work within an hour, but for the full effects, it may take longer
Coffee contributes to your fluid intake, but its mild diuretic effect means its smart to follow it with water, especially if you're taking a GLP-1
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Prado CL, Pugh-Bernard AE, Elghazi L, Sosa-Pineda B, Sussel L
Both work through the same receptor mechanism, but compounded formulations from licensed 503A pharmacies bypass some manufacturing overhead
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