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Trial durations vary

[13] Fasting levels of insulin-like growth factor (IGF) binding proteins such as IGFBP1 and IGFBP2 increased after tirzepatide treatment, increasing insulin sensitivity

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Notably, potential toxicity of accumulated metals can be decreased as a result of the formation and subsequent sequestration of metal-PC complexes in vacuoles via transport across the tonoplast (Cobbett and Goldsbrough, Caenorhabditis elegans PCS gene that control PCs production