Itoh et al., 2004
demonstrated that blockage of the cannabinoid receptor-1 using CB1 antagonists lowered gut permeability and adipogenesis in obese mice, through normalizing Occludin and ZO-1 expression, whereas CB1 stimulation increased permeability markers both in vivo and in vitro [27]
Preclinical studies have found that berberine increases the number of tyrosine hydroxylase (TH)-positive neurons in the substantia nigra, at the same time, berberine also increases striatum dopamine, norepinephrine, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid levels (Shin et al., 2013)
Restore your bodys natural resilience
TB-500 is derived from thymosin beta-4, a naturally occurring peptide involved in actin cytoskeleton regulation and cellular movement, which makes it useful in studies examining cytoskeletal organization and cell motility
Bring results from your primary care provider (dated within 3-6 months) to potentially skip this step