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When exercise was added, these negative effects were largely prevented: exercised rats had higher total bone mineral content, lean mass, and serum IGF-1, and their bone mechanical strength was maintained despite reduced energy availability

Tozzi, Giulia

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Introduction Injury recovery often involves long weeks or months of rest, physical therapy, and sometimes surgery

IGF-1 LR3 has been used extensively in this context precisely because its extended half-life allows sustained receptor activation in cell culture and in vivo models without the impractical dosing frequency that native IGF-1 would require