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Delayed gastric emptying can increase intragastric pressure and potentially promote gastroesophageal reflux, particularly in patients with pre-existing GERD or those who overeat despite reduced appetite signals

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Patients should be monitored for serious adverse events including pancreatitis (severe abdominal pain radiating to the back, with or without vomiting), gallbladder disease, acute kidney injury (particularly with dehydration from persistent GI symptoms), diabetic retinopathy complications (with Ozempic/Rybelsus), and hypoglycemia (especially when used with insulin or sulfonylureas)

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