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Nature [^7]: Miller CA, Golden KD, Mallett AK, et al
NRH salvage and conversion to NAD+ requires NRH kinase activity by adenosine kinase
CJC-1295 is not for everyone -suitability is assessed at consultation
The overall rate of treatment discontinuation due to adverse events was described as relatively low across published trials
The groups most likely to develop B12-related hair and skin changes are the same ones at risk for deficiency generally: vegans and vegetarians, adults over 50, people on long-term metformin or proton pump inhibitors, anyone who's had bariatric surgery, and people on GLP-1 protocols whose reduced appetite has significantly lowered their overall nutrient intake for an extended period
In the absence of DsbA, this redox potential shifted to a more reducing -243 mV
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