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One Mayo Clinic forum discussion acknowledged that an alternating 6-month approach is "creative" and might allow you to get benefits from both while minimizing cumulative side effects

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When some nephrons are injured or lost, the remaining healthy nephrons undergo a process called adaptive hyperfiltration

While the prescribing information for GLP-1 medications does not specifically list Crohn's disease as a contraindication, the Summary of Product Characteristics (SmPC) for these medicines does advise caution in patients with gastrointestinal disease and states they are not recommended in severe gastrointestinal disease

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The digestive system slows, which may lead to early nausea, bloating, or constipation