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The secondary structure analysis of the predicted structures (except DrugBank peptides) revealed that the peptide residues frequently belong to loop regions (~32%), followed by helix (~30%), turns (~17%) and bends (~19%)

However, previous studies have not resolved certain questions: i) whether alterations in the identified proteins and metabolites are affected by eye drops, ii) how these changes in proteins and metabolites are affected by glaucoma phenotype, and iii) whether normal-tension glaucoma shows protein and metabolite changes in the same way as POAG