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doi: 10.3389/fimmu.2021.652252 155 LabarrereC

The clinical relevance of lymphatic and blood-vessel invasion in breast-cancer patients

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FIGURE 9 Summary and conclusions: Glutathione and early (premature) inflammaging Chronic inflammatory diseases especially those compromising the lower respiratory system (chronic obstructive pulmonary disease, lower respiratory infections, cystic fibrosis, idiopathic pulmonary fibrosis, acute respiratory distress syndrome), diseases compromising the cardiovascular system (atherosclerosis, ischemic heart disease, stroke, and others), many other systemic inflammatory diseases like diabetes (274, 275)

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Treatment with 32-134D reduced the hypoxia-induced expression of genes associated with tumor metabolism and immune evasion, such as PD-L1, while enhancing the activity of CD8 + IFN- + T cells and NK cells, key players in antitumor immunity [22]