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Supraphysiologic use raises levels beyond what the body would usually maintain, which changes the risk profile and should not be confused with routine hormone optimization

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We have seen in the data that even without significant blood sugar lowering, there seemed to be some sort of anti-inflammatory effects, so we dont really know the mechanism yet, but some people do microdose it for autoimmunity. Shafer himself has made the switch to retatrutide after taking other GLP medications and plateauing

doi:10.1073/pnas.1522014113 16

Review links 3 potentially-blinding eye conditions to GLP-1 drugs like Ozempic

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