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In a 12-week double-blind, placebo-controlled, split-face study involving 93 women aged 3555, a moisturiser containing 3 parts per million palmitoyl-KTTKS produced statistically significant improvements in fine lines and wrinkles compared with the otherwise identical vehicle

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The study lacked a young reference cohort

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Triplex formation with the modified oligonucleotide appears to occur with approximately equivalent binding affinity