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Ranging from cell proliferation, cell differentiation and apoptosis, tissue growth, and organ-specific functions, the biological functions of IGF-1 and its measurement have been deemed significant

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Tumor cells with mesenchymal phenotype are resistant to the dual IGF-IR/InsR inhibitor linsitinib, due to the decreased expression of IGF2 and InsR, and phosphorylation of IGF-IR/InsR in these cells [182]

On the one hand, active platinum ions bind to the genomic DNA of tumor cells to form platinumDNA adducts, block DNA replication and transcription, and ultimately mediate tumor cell apoptosis/necrosis to exert anti-tumor effects

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A more recent Phase I safety trial on healthy volunteers was started in 2015 but puzzlingly, the researchers never published the results , and the trial record was marked completed with no data release