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Different types of study participants: The studies had different types of people

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The original preclinical study used a GCGR antibody antagonist to isolate the GCGR contribution in DIO mice: GCGR blockade significantly blunted weight loss and blocked the LY3437943-induced increase in energy expenditure without affecting caloric-intake reduction

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Cuatrecasas P: Protein purification by affinity chromatography

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