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Furthermore, it has been indicated that their deficiency is linked to reduced DNA methylation due to the disruption of DNMT enzymes 33,34

Instead, GH travels to the liver and stimulates the production of insulin-like growth factor 1 (IGF-1)

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For this reason, ipamorelin is commonly referred to as a ghrelin mimetic. It selectively binds the same GHSR-1a receptors as endogenous ghrelin and stimulates the pituitary cells to release more GH