If your symptoms worsen progressively over weeks despite being at a stable dose and past the transition period, something beyond simple pharmacokinetics may be at play
10.1186/s12889-022-13734-4 39 McCabeaS
Endosomal-sorting complexes required for transport (ESCRTs), which recognize ubiquitylated proteins, are the most characterized one among genesis pathways, while others may involve sphingomyelinases (Trajkovic et al., 2008), sphingosine-1-phosphate, and tetraspanin-enriched domains (McGough and Vincent, 2016)
The inhibition or blocking of VGSCs can control the seizure (Agbo et al., 2023)
So B5 is always added to our IV Therapy treatments for fatigue
These are rare and saffron is even being explored as a mood stabiliser