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Several practical factors may explain fatigue during GLP-1 therapy: Reduced food intake due to appetite suppression can lead to lower energy consumption Gastrointestinal side effects like nausea can be physically draining Adaptation to metabolic changes as your body adjusts to the medication For people with diabetes who take insulin or sulfonylureas (like gliclazide) alongside GLP-1 medications, low blood glucose (hypoglycaemia) may cause fatigue

Prescriptions are issued only when clinically appropriate

It also does not increase ghrelin levels in the body, so it does not cause side effects such as increased hunger

However, persistent or severe headaches warrant medical evaluation to exclude other causes and ensure appropriate management

Methods Ethical approval All animal experiments reported herein were performed following the guidelines and were approved by Peking University Institutional Animal Care and Use Committee (LA2021316)

Why Diet Matters While Taking Tirzepatide Tirzepatide affects hormones that regulate appetite, blood sugar, and digestion