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Collectively, our observations indicate that GCLM KO mice exhibit hepatic and systemic oxidative stress

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Ethics declarations Competing interests SK reports grants from Medical Research Council and from GSK for conduct of the current study

Apart from that, the activation of Nrf2 by chlorogenic acid restores mitochondrial ion protein homologue (Lon) protein expression and reduces mitochondrial HSP60 release, attenuating APAP-induced inflammatory liver injury ( Caffeic acid is a common phenolic chemical found in a wide variety of plants