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Platelets contain alpha granules packed with growth factors: platelet-derived growth factor (PDGF), transforming growth factor beta (TGF-B), insulin-like growth factor (IGF-1), and others

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Interestingly, the same pathway may also be utilized during inflammatory responses, mediated by the tumor necrosis factor-alpha (TNF-)

247 Second, clinically-important subgroups could be identified a priori and evaluated for treatment responses

Among these GPxs, 5 selenium-dependent GPx isozymes have been identified (Table 1)