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But try to maintain consistency, especially during the first 8 weeks when the accumulation to steady state matters most

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If Phase II is too slow, the reactive Phase I intermediates accumulate and cause oxidative damage, DNA mutations, and cellular inflammation

Mar 2015;58(3):596-603

A mitochondria-targeted covalent organic framework (COF) prodrug that is selectively activated by high intramitochondrial GSH levels was shown to trigger catalase collapse within the organelle, thereby amplifying local chemodynamic therapy (CDT) through enhanced ROS accumulation and mitochondrial dysfunction