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Possibly the IDEAL trial (Cooper et al, NEJM 2010) may have also contributed in the 2010s to later (and lower) dialysis starts, as early initiation of dialysis therapy failed to show any clinical or survival benefits
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Separately, GLP-1 RAs are not recommended during pregnancy, and individuals of childbearing potential are advised to use effective contraception throughout treatment
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Differential GLP-1R binding and activation by peptide and non-peptide agonists
That said: Skin irritation: Some people experience mild scalp irritation, especially with higher-concentration formulations or poorly formulated vehicles
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