Study: TripleHormone Receptor Agonist Retatrutide for Obesity (Phase 2 Trial, NEJM) Drug: Retatrutide a triple agonist (GLP-1, GIP, and glucagon receptors) Key Findings: Up to 28.7% mean weight loss at higher doses Marked improvements in insulin sensitivity and cardiometabolic risk factors Weight loss approaching outcomes seen with bariatric surgery, without surgery What makes Retatrutide unique is its triple-hormone mechanism, simultaneously targeting appetite regulation, energy expenditure, and glucose metabolism
Ozempic Dosage for Weight Loss The Ozempic dosage for weight loss is typically titrated up to a maximum dose of 2mg weekly, as tolerated by each individual patient
Providers and patients seem to choose these therapies more often now, since the clinical effectiveness feels more convincing in day to day practice
The trial also showed kidney benefits in patients with and without concomitant SGLT2i use, highlighting the independent and added effects of these agents
358 , e4 (2008)
Best Sources: Lean meats (chicken, turkey, lean beef) Fish and seafood Eggs (especially important for biotin) Greek yogurt and cottage cheese Legumes (beans, lentils) Collagen peptides (particularly beneficial for hair) High-quality protein powders if food intake is insufficient Pro Tip: Distribute protein throughout the day rather than loading it all in one meal