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It has been broadly shown to be equally efficacious
It shares a high degree of sequence similarity in the TMD region with GLP-1R (61%) that has been studied extensively both structurally and functionally
Receptor GLP-1 i receptor GIP to dwa ramiona osi inkretynowej o odrbnych rolach
Important limitations include: Most evidence derives from preclinical or observational studies No randomized controlled trials specifically evaluate tirzepatide for autoimmune disease Mechanisms remain incompletely understood Clinical translation of anti-inflammatory effects is uncertain There is currently no established clinical evidence that tirzepatide effectively treats autoimmune diseases
12 In high concentrations, GLP-1RAs show lipolytic activity
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