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The aim of this study was to evaluate the effectiveness and tolerability of tirzepatide treatment using three different dose-escalation regimens in patients with type 2 diabetes

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Apart from this, metformin can cause changes in the microbial composition of the intestinal tract (Vallianou et al., 2019), increased lactic acid production (Misbin et al., 1998), and increased concentrations of glucagon-like peptide-1 (GLP-1) and bile acids (Mannucci et al., 2004

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