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The main safety concern is QTc prolongation, particularly at higher doses or in combination with other QT-prolonging medications

Is There a Drug Interaction Between Bupropion and Semaglutide

One of the most documented concerns with GLP-1 receptor agonist therapy is the loss of lean body mass during treatment

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Author Contributions Aleksandrina Ruseva, Wojciech Michalak, Anthony Fabricatore, Brain Hartaigh, and Zhenxiang Zhao were responsible for the study concept and design, data interpretation and analysis, drafting/revising the manuscript, and reviewing/approving the final version for submission