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Although the direct cytotoxic effects of high cellular GSSG levels have been documented in a variety of cell types 33,34,35,36 , our cell culture studies with hepatocytes revealed that increased GSSG accumulation, despite being non-toxic per se, could sensitize hepatocytes to TNF-induced killing, suggesting that GSSG and TNF can synergistically induce hepatocyte death and that GSSG-triggered sensitization to TNF hepatotoxicity represents a clinically relevant process that may account for disease progression in NAFLD

It is a synthetic peptide that has been studied mostly in preclinical and limited experimental settings

A vial that arrives mislabeled or contaminated produces a problem the patient cannot detect

In particular, S1PR1 signaling promotes the assembly and maintenance of adherent junctions (Hirase et al., 2001

J Hum Nutr Diet

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