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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

In response to oxidants, cysteine modification on Keap1 releases NE2FL2, which is then stabilized and transported to the nucleus where it activates transcription of antioxidant genes, including proteasomal PA28

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PMID: 31318637 Goldstein AL, et al

Extracellular vesicles and soluble factors secreted by Escherichia coli Nissle 1917 and ECOR63 protect against enteropathogenic Escherichia coli -induced intestinal epithelial barrier dysfunction

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