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In subjects with T2DM, weekly administration of tirzepatide at doses of 5 mg, 10 mg, or 15 mg was associated with greater weight loss compared to placebo ( 6.3 kg, 8.4 kg, and 9.4 kg, respectively), and 1.7 kg, 4.8 kg, and 7.2 kg greater weight loss compared to selective GLP-1 receptor agonists, demonstrating a dose-dependent effect sustained for up to 2 years [48]

Healthier, more plant-based, diets may be about 25 percent less expensive

All participants in the orforglipron arm began the trial at a dose of 1 mg orforglipron daily, and then increased the dose in a stepwise approach at 4-week intervals until reaching their randomized maintenance dose of 12 or 36 mg

Pregnant individuals, people with chronic medical conditions, and patients taking prescription medications should consult a healthcare provider to evaluate potential risks or interactions

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Below 1,000 calories, most people cannot meet basic nutritional needs