Chronic low-grade inflammation, increasingly recognized as a contributor to numerous age-related health conditions, may be partially mediated by inadequate antioxidant defenses including suboptimal glutathione status
In the case of GSTs, these multifunctional and essential enzymes are involved in many processes, such as detoxification, signaling, redox homeostasis, plant metabolism, growth regulation, and adaptation to biotic and abiotic stress ( Tobamovirus ( Geminivirus ( Tenuivirus ( A relatively low number of studies have focused on the importance of the glutathione cycle and glutathione-associated enzymes in plant cell responses, both compatible and incompatible, or their potential role in developing resistance to plant viruses
PMC / Int J Mol Sci
Given the genetic heterogeneity of pediatric cataracts, further integrative genomic studies are warranted to define the precise contribution of CYP51A1 to lens development and to explore its potential as a diagnostic marker or therapeutic target in congenital cataract syndromes
Luminescence (black bars) was normalized to vehicle (0.1% DMSO)
& Frigione, M