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Under ad libitum fed conditions, the ability to activate -oxidation plays a predominant role in longevity, as evidenced by a 41% reduction in lifespan in nhr-49(nr2041) mutants
published in Frontiers in Physiology confirmed that BPC-157 dose- and time-dependently increased GHR expression in isolated rat Achilles tendon fibroblasts at both mRNA and protein level, and that GH added to BPC-157-treated fibroblasts produced significant, dose-dependent increases in cell proliferation establishing GHR upregulation as a specific molecular mechanism through which BPC-157 enhances local tissue sensitivity to growth hormone signalling
The Journal of nutrition , 131 (11), pp.3095S-3108S
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