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Sequential therapy is more common in clinical practice, and decisions should be made promptly within 36 months and based on clinical or biochemical established goals

Farmer, R

Other poor predictors of outcome are old age, female sex, high AST

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Both doses administered in PD patients were followed by more than 50 % inhibition of LRRK2 and Rab10 phosphorylation in blood, and reduced bis (monoacylglycerol) phosphate in urine, which served as biomarkers of pharmacodynamic measures, and the lower dose was better tolerated