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This is the most plausible explanation for why retatrutide's Phase 2 weight-loss readouts (up to 24.2% at 48 weeks) sit above comparable tirzepatide and semaglutide datasets [3][11]

Whitfield et al., 2015

When they are, ATP production runs more consistently, which directly supports endurance, power output, and the ability to sustain effort across a training block

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It also supports weight loss and is essential for all bodily functions

Some research suggests L-carnitine may help preserve lean muscle mass during calorie restriction, though more studies are needed