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[145] FosB is the most significant biomolecular mechanism in addiction because FosB overexpression (i.e., an abnormally high level of gene expression which produces a pronounced gene-related phenotype) in the D1-type medium spiny neurons in the nucleus accumbens is necessary and sufficient [note 13] for many of the neural adaptations and regulates multiple behavioral effects (e.g., reward sensitization and escalating drug self-administration) involved in addiction

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[151] Pharmacological treatments As of December 2019,pharmacotherapy for amphetamine addiction

They are a multifunctional complex that forms a seal between adjacent epithelial cells near the apical surface (Figure 2)