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To date, only two trials have put dietary interventions to the test for major depression: the SMILES trial and the HELFIMED trial

Moreover, all included studies were observational in nature, making them susceptible to residual confounding and selection bias

A recently published study in The British Medical Journal found that overweight or obese adults regained the weight they had lost within 1.7 years once they stopped taking the drugs

Weight loss while on the drugs can vary, with some people losing as low as five pounds to thirty pounds or higher

When AMPK is activated, it may trigger metabolic effects including improved insulin sensitivity, enhanced glucose uptake by cells, and reduced glucose production in the liver