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Allergy (2016) 71(1):6876
5, SeNPs exert their anti-ferroptotic effects in renal tubular epithelial cells through a stepwise mechanism: they are first internalized into the cytoplasm via endocytosis, subsequently enriched within lysosomes, and then stimulate XBP1 expression to block I/R-induced excessive activation of NCOA4-mediated ferritinophagy, ultimately interrupting iron-dependent cell death cascades
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