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TMPRSS2 expression dictates the entry route used by SARS-CoV-2 to infect host cells

and Ida Green Professorship in System Biology (to J.Z.) from the University of Texas at Dallas

These findings have important clinical ramifications with the possibility of targeting ferroptosis pathway in GPX4-overexpressing thyroid cancers

Primary antibodies were obtained as follows: Anti- ER-alpha, Anti-PARP, Anti-Cleaved Caspase-3, Anti-PARP and Anti-P-SAPK/JNK were from Cell Signaling (Danvers, MA, USA), Anti-4HNE and Anti -actin was from Abcam (Toronto, ON, Canada), Anti-GAPDH and Anti--Tubulin was from (Sigma), Anti-Nrf2 (H-300) and Anti-NQO1 (A180) were from Santa Cruz (Santa Cruz, CA, USA), Anti-Calnexin was from Enzo Life Sciences (Farmingdale, NY, USA) and Anti-GPR30 was from Genscript (Piscataway, NJ, USA)

You must consult with a trained healthcare expert to identify the best treatment plan for your specific needs, preferences, and medical concerns

There was no significant difference in glutathione levels in the deproteinized fraction