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Cortisol and ACTH are hormones potentially involved in the stress response and are typically associated with various metabolic and immune actions

Blocking FOXO4, which inhibits the activation of P53, causes senescent cells to undergo apoptosis by P53 activation, without affecting healthy cells around them, and has anti-aging effects which may have potential applications in the treatment of numerous age-related diseases, as well as an adjunct to treatment for certain forms of cancer

PMID 12427732

Histone lysine acetyltransferase inhibitors: an emerging class of drugs for cancer therapy