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Mood and appetite, he explained, are closely related (think of stressful eating or eating when we are sad, comfort food), and a benefit of [GLP-1 drugs] is that they help control appetite and satiety, which allows patients to make better meal choices and become healthier. So, the modest improvement in depression seen in the study may be related to weight loss, improved blood sugars, [fewer diabetes] symptoms, and likely an overall sense of patients getting healthier, Splenser hypothesized
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As a bonus, it supports the secretion of immune cells and tissue repair
In case non-inferiority is reached at the end of the study, a statistical testing for superiority (cardiovascular benefit of the tested novel substance) can be performed
With ongoing research and clinical advancements, retatrutide holds promise for enhancing metabolic health and ultimately improving the overall well-being of individuals struggling with metabolic disorders