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While tirzepatide and semaglutide are both GLP-1 receptor agonists that help with weight loss by regulating appetite and blood sugar, tirzepatide has an additional action as a GIP receptor agonist, which means it targets another hormone involved in metabolism and insulin regulation

This means less downtime between workouts, reduced inflammation, and quicker adaptation to training loads

Lau, David C W

And for those comparing across the triple agonist space, mazdutide versus retatrutide and Ozempic versus retatrutide provide helpful context

When injecting Ozempic in the stomach, choose a spot at least 2 inches away from your belly button and avoid your waistline to prevent clothing rubbing against the injection site and creating irritation

Medical Contraindications These include a personal or family history of medullary thyroid carcinoma, a diagnosis of Multiple Endocrine Neoplasia syndrome type 2, or known hypersensitivity to semaglutide or other medication components