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Panel B of Figure 5 shows that the fluctuations in methionine input cause very large fluctuations in SAM but only modest fluctuations in intracellular methionine concentration, as suggested by the early methionine loading experiments of Finkelstein and co-workers [53, 54]
doi: 10.2215/CJN.04840419 65 CurciCCastellanoGStasiADivellaCLoverreAGiganteMet al
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SAM = S-adenosylmethionine
It can be improved within 1-2 weeks, whereas some chronic diseases, such as arthritis or tissue regeneration, can require 4-6 weeks or more
PCD, Programmed cell death
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